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What will a month cost?
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Published
September 2026

Sermorelin Tablets: What the Oral Form Costs Against the Injection

The monthly price of compounded sermorelin tablets beside the drop under the tongue and the injection, why a pharmacy may make a tablet when the approved product was a shot, and what a swallowed peptide is up against.

ByDerek MossPricing analystPublished

A month of sermorelin tablets runs a typical $189 from sellers that publish a price. The injection runs $189. The tablet is the newer listing of the three, and the thinnest. The sermorelin price board carries every seller behind these figures.

Compounded sermorelin, per month, by route, September 2026
Tablet (swallowed)Under the tongueInjection
Lowest published month$95$89$90
Typical (median) month$189$169$189
Highest published month$299$299$349
Sellers publishing a month1918140
Compounded sermorelin, per month, by route, September 2026. Computed from every tracked seller that publishes a monthly figure for that route, each counted once at its lowest month.

The spread inside each column is wider than the gap between columns. That is the practical point: the route matters less to the bill than which seller writes it. The sermorelin cost guide breaks a single month into its parts.

Why a pharmacy may make a sermorelin tablet at all

Federal law lets a pharmacy compound from a bulk substance in three cases[1]. One of them is a substance that is a component of a drug the agency has approved[1].

Sermorelin qualifies through GEREF. FDA determined on March 4, 2013 that GEREF was not withdrawn from sale for reasons of safety or effectiveness[2].

That condition names a substance, not a route. Nothing in it limits a compounder to the dosage form the approved product used. More on the status is in is sermorelin FDA approved.

What the approved product actually was

Both GEREF applications were injections[2]. One covered 0.5 mg and 1.0 mg base per vial, under NDA 20-443[2]. The other covered 0.05 mg base per ampule, under NDA 19-863[2].

Their holder discontinued both in 2008 and asked FDA to withdraw the applications[2]. No approved sermorelin tablet has ever existed in the United States.

One more condition of the law matters here. A pharmacy may not regularly compound copies of a commercially available drug product[1]. No sermorelin product is commercially available to copy.

What a swallowed peptide is up against

Peptides are unstable in the gut. A 2025 review describes rapid breakdown by digestive enzymes and acid[3]. Absorption is poor because the molecules are large and water-loving[3].

The mouth is the alternative that route claims. The review notes the lining there is well supplied with blood and skips first-pass liver metabolism[3].

It also names the costs of that shortcut. The lining limits what crosses, saliva washes the dose away, and enzymes in saliva break peptides down[3].

No published human study gives sermorelin by mouth. PubMed indexes 332 sermorelin records. Two of them mention a tablet, lozenge or sublingual route, and neither describes dosing a person that way.

Questions worth asking before the first refill

  • Is the tablet swallowed or held under the tongue, and for how long?
  • How many milligrams per tablet, and how many tablets a month?
  • Does the quoted price include the consult, and what does month two cost?

The last one is where most of the money moves. Turning a vial or bottle into a per-month figure is set out in how long a sermorelin vial lasts. The visit itself is covered in sermorelin prescription.

FAQ

4 questions

Are sermorelin tablets cheaper than sermorelin injections?

This page computes both from every tracked seller that publishes a monthly price, and the gap between the two routes is smaller than the spread inside either one. Which seller writes the prescription moves the bill more than which route it is for.

Is there an FDA-approved sermorelin tablet?

No. The two approved sermorelin products, both sold as GEREF, were injections under NDA 20-443 and NDA 19-863, and both were discontinued in 2008. A compounded tablet is not an approved product.

Why can a pharmacy compound sermorelin as a tablet?

Federal law allows compounding from a bulk substance that is a component of an approved drug. That condition attaches to the substance rather than to the dosage form, and no commercially available sermorelin product exists for a compounded tablet to copy.

Do sermorelin tablets work as well as the injection?

No published human study gives sermorelin by mouth, so there is nothing to compare. A 2025 delivery review describes peptides being broken down rapidly by digestive enzymes and acid, and absorbed poorly because of their size and water affinity.

Sources

3 cited
  1. [1]United States Code (2024). 21 U.S.C. 353a, Pharmacy compounding Office of the Law Revision Counsel. Source
  2. [2]Food and Drug Administration (2013). Determination That GEREF (Sermorelin Acetate) Injection, 0.5 Milligrams Base/Vial and 1.0 Milligrams Base/Vial, and GEREF (Sermorelin Acetate) Injection, 0.05 Milligrams Base/Amp, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness Federal Register, 78 FR 14095. Source
  3. [3]Amer AA, Bingle L, Elkordy AA, Chaw CS (2025). Overcoming Oral Cavity Barriers for Peptide Delivery Using Advanced Pharmaceutical Techniques and Nano-Formulation Platforms Biomedicines. PMID 41301828